GENETIC VARIATION IN B-TYPE NATRIURETIC PEPTIDE PATHWAY AFFECTS BNP Research Proposal - 1

GENETIC VARIATION IN B-TYPE NATRIURETIC PEPTIDE PATHWAY AFFECTS BNP LEVEL in the diagnosing of Heart failure - Research Proposal ExampleTo help establish the break throughcomes, the study go out be embedded on extracting DNA samples from 80 patients undergoing elective cardiac catheterization and analyzing with exclusion done on patients with elevated troponin. This will be driven by a detailed data collection including laboratory, pattern demographic, catheterization and echocardiographic data.The Genotype will be evaluated at 19 loci on five BNPs pathway applicable genes (Knowles, Erickson, Guy et al, 2003). To access the incremental influence of the genetic variants, the researcher will employ the Multivariate additive regression of logBNP model adjusted for clinical variables. The proposal will thus try to help mightily incorporate the use of NPs to improve the levels of accuracy with respect to decisions made in an emergency setting to bottle up the missed incidence of di agnostic failures for HF. This will be measured by reduced cases of fatigue, dyspnea, and fluid holding that are all predisposing factors to HF based on cardiac dysfunction hence presenting difficulties in name HF. The missed incidence are hence strongly correlate to highly significant mortality increases, presenting the accept for designing effective diagnostic tools with higher degrees of specification and sensitivity that if employed, can help weed out the increased cases of HF missed diagnoses and particularly, in the busyHeart failure is characterized by its typical only when non-specific symptoms like fatigue, dyspnea and fluid retention caused by dysfunction of cardiac which present daunting challenges for diagnosis of HF culminating into increased missed incidence hence higher mortality rates. For this reason, the topic has captured the attention of mixed researchers to help design effective mechanism and approaches that can be used during diagnosis to detect this ruino us cardiovascular disease quickly and accurately. For instance, to gauge the potentiality of NPs in augmenting the clinical judgment and/or streamer